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Human amelogenesis: high resolution electron microscopy of nanometer-sized particles
F J Cuisinier1, P Steuer, B Senger
1Centre de Recherches Odontologiques, INSERM, Strasbourg, France.
Cell and Tissue Research
|July 1, 1993
Summary
Human enamel crystal growth involves ribbon-like crystals and nanometer-sized particles. These particles may represent an early apatite precursor phase, guiding crystal development during amelogenesis.
Area of Science:
- Biomineralization
- Crystallography
- Dental Enamel Formation
Background:
- Enamel crystal growth is a complex, multi-stage process.
- Understanding early crystal formation is key to comprehending enamel development.
Purpose of the Study:
- To investigate the nature and role of nanometer-sized particles during human enamel crystal growth.
- To elucidate the relationship between these particles and ribbon-like crystal development.
Main Methods:
- Analysis of crystal structures and lattice parameters.
- Observation of particle size, distribution, and evolution during amelogenesis.
Main Results:
- Identified nanometer-sized particles (1.1 nm mean diameter) during early amelogenesis.
- These particles exhibit crystalline structure, potentially representing an apatite precursor phase.
- Observed particle growth and proximity to ribbon-like crystals suggest a role in crystal development.
Conclusions:
- Nanometer-sized particles are likely an initial stage in apatite crystal formation during enamel growth.
- These particles may act as precursors, influencing the development of ribbon-like enamel crystals.
- Nucleation sites on ribbon-like crystals could facilitate both ribbon elongation and particle formation.