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Microanatomy of the intravesical ureter in children with and without reflux

E Hammar, I Helin

    The Journal of Urology
    |March 1, 1977
    PubMed

    Insights

    Microscopic examination of children's ureters revealed no significant differences in fibrosis or inflammation between those with recurrent urinary tract infections and vesicoureteral reflux and those without. This suggests these conditions may not cause distinct ureteral tissue changes detectable microscopically.

    Area of Science:

    • Pediatric Urology
    • Pathology
    • Nephrology

    Background:

    • Recurrent urinary tract infections (UTIs) and vesicoureteral reflux (VUR) are common in children.
    • The long-term effects of these conditions on ureteral tissue are not fully understood.

    Purpose of the Study:

    • To compare the microscopic features of distal ureters in children with recurrent UTIs and VUR to those without urinary tract disease.

    Main Methods:

    • Microscopic examination of 37 distal ureteral resection specimens from children with recurrent UTIs/VUR.
    • Comparison with 51 postmortem distal ureter specimens from children without urinary tract disease.

    Main Results:

    • Significant variation in fibrosis and inflammatory changes was observed in both study groups.
    • No discernible microscopic differences were found between the ureters of children with and without a history of UTIs and VUR.

    Conclusions:

    • Microscopic analysis did not reveal distinct pathological changes in the distal ureters of children with recurrent UTIs and VUR compared to controls.
    • Further research may be needed to identify potential subtle or functional changes associated with these pediatric conditions.

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