Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular Ca2+ sensing by the osteoclast

M Zaidi1, A S Alam, C L Huang

  • 1Division of Biochemical Medicine, St George's Hospital Medical School, London, UK.

Cell Calcium
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining EBV DNA dynamics with RECIST-based radiographic response to improve prognostic stratification of recurrent/metastatic nasopharyngeal carcinoma in the era of immunotherapy.

Rhinology·2026
Same author

Advances in tooth agenesis and tooth regeneration.

Regenerative therapy·2023
Same author

[Gd-EOB-DTPA MRI features of hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma: a case report].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2022
Same author

[Bivariate heritability estimation of resting heart rate and common chronic disease based on extended pedigrees].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2020
Same author

[Fujian Tulou Family Cohort Study: study design and characteristics of participants and pedigrees in baseline investigation].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2018
Same author

Beyond ONJ - A review of the potential uses of bisphosphonates in dentistry.

British dental journal·2017
Same journal

Calorie restriction modulates beta cell IP<sub>3</sub>R activity to regulate Ca<sup>2+</sup> homeostasis and cell network connectivity.

Cell calcium·2026
Same journal

Spatially multiplexed stimulation reveals nonlinear calcium signaling in platelets.

Cell calcium·2026
Same journal

Calcium handling properties and arrhythmia vulnerability of cardiomyocytes from dystrophin-deficient mdx mice.

Cell calcium·2026
Same journal

Molecular actors of the Calcium signaling in the endothelial-to-mesenchymal transition: poorly explored therapeutic targets.

Cell calcium·2026
Same journal

High-throughput quantitation of pathogen-induced calcium signals captured through live-cell fluorescence microscopy.

Cell calcium·2026
Same journal

A model for the complete sequence of the human voltage-gated calcium channel (Ca<sub>V</sub>1.2) in a lipid bilayer.

Cell calcium·2026
See all related articles

Osteoclasts sense extracellular calcium (Ca2+) levels, altering bone resorption and cell motility. This calcium sensing involves surface receptors and intracellular calcium release, crucial for bone remodeling.

Area of Science:

  • Cell Biology
  • Physiology
  • Biochemistry

Background:

  • Cells increasingly detect extracellular Ca2+ concentrations to modify function.
  • Osteoclasts play a critical role in bone resorption and remodeling.
  • Extracellular Ca2+ acts as both an external signal and an internal messenger, complicating analysis.

Purpose of the Study:

  • To review evidence for extracellular Ca2+ detection mechanisms in osteoclasts.
  • To understand how osteoclasts respond to changes in extracellular Ca2+.
  • To elucidate the role of Ca2+ signaling in osteoclast function.

Main Methods:

  • Review of existing scientific literature on osteoclast Ca2+ signaling.
  • Analysis of how elevated extracellular Ca2+ affects osteoclast bone resorption and motility.

Related Experiment Videos

  • Investigation of cytosolic Ca2+ changes using electrophysiological methods (K+ and valinomycin) and surrogate activators (CIO4-, Ni2+, Cd2+).

    • Main Results:

    • Elevated extracellular Ca2+ (mM range) reduces osteoclast bone resorption and alters cell motility.
    • Cytosolic Ca2+ increases are triggered by surface Ca2+ receptor activation.
    • Extracellular Ca2+ contributes to cytosolic Ca2+ elevations, alongside Ca2+ release from intracellular stores.

    Conclusions:

    • Osteoclasts possess a mechanism to detect and respond to extracellular Ca2+ concentrations.
    • This sensing involves both direct extracellular Ca2+ influx and intracellular Ca2+ release.
    • Understanding osteoclast Ca2+ handling provides insights into bone physiology and potential therapeutic targets.