Related Experiment Video
Updated: Aug 4, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
Overgrowth management in Klippel-Trenaunay-Weber and Proteus syndromes
K J Guidera1, M R Brinker, B G Kousseff
1Shriners Hospital for Crippled Children, Tampa Unit, FL 33612-9499.
Abstract:
Twenty-eight patients with limb overgrowth and the diagnosis of Klippel-Trenaunay-Weber or Proteus syndromes were evaluated retrospectively. These disorders are part of the phakomatosis spectrum of syndromes. The orthopedic problems consisted of asymmetric limb overgrowth, localized gigantism, angular deformities, scoliosis, vascular malformations, and skin anomalies. Systemic abnormalities are common and deserve full evaluation before treatment. Surgical treatment consisted of epiphysiodesis, osteotomies, debulking procedures, and amputation. Mixed results were obtained with surgery, and conservative or supportive treatment should be the primary mode of orthopedic care.
Related Concept Videos
Abnormal Proliferation
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Regulation of Angiogenesis and Blood Supply
Abnormal Proliferation
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Aneurysm III: Interprofessional Care

