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MRI of pancreatic islet cell carcinoma
B Carlson1, C D Johnson, D H Stephens
1Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55905.
Objective:
The purpose of this study is to report the spectrum of MR findings of pancreatic islet cell carcinoma.
Materials And Methods:
The MR scans of 33 patients with islet cell carcinoma were retrospectively reviewed. Magnetic resonance detected the primary tumor in 21 of 27 patients (78%) who had not had prior resection of their primary tumor. Mean tumor diameter was 7.1 cm (range 3.5-13.0 cm).
Results:
In all patients, the primary tumor on T1-weighted images (TR/TE = 250/15) was of signal intensity equal to or lower than that of the adjacent normal pancreas. The primary tumor on T2-weighted images (TR/TE = 2,000/> or = 100) was of signal intensity the same as or higher than fat in 18 of 21 patients (86%) and had mixed signal intensity in the other 3 (14%). Hepatic metastases were found in 28 of 33 patients (85%). Liver metastases were categorized as "usual" (variably circumscribed, homogeneous lesions of medium signal intensity on T2-weighted images) in 19 of 28 patients (68%), necrotic in 8 of 28 (29%), hemorrhagic in 3 of 28 (11%), and calcified in 1 of 28 (4%). Extrahepatic metastases were found in 18 of 33 patients (55%).
Conclusion:
We conclude that MRI is an excellent modality for the diagnosis and routine follow-up of patients with islet cell carcinoma.