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Paget disease of the nipple: radiologic-pathologic correlation
D M Ikeda1, M A Helvie, T S Frank
1Department of Radiology, University of Michigan Hospitals, Ann Arbor.
Radiology
|October 1, 1993
Summary
Paget disease of the nipple can present with varied clinical and mammographic findings. Correlation with physical examination is crucial for diagnosis, especially with nonspecific nipple-areolar changes.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Paget disease of the nipple is a rare condition.
- It is often associated with underlying breast cancer.
Purpose of the Study:
- To correlate clinical presentations with mammographic and histologic findings in Paget disease of the nipple.
- To improve diagnostic accuracy for Paget disease.
Main Methods:
- Retrospective review of clinical, pathologic, and mammographic records of 58 patients.
- Inclusion of data from two previous studies.
Main Results:
- In patients with typical Paget disease, 50% had normal mammograms, 29% showed nipple-areolar abnormalities, and 21% had masses or calcifications.
- In patients without clinical findings, 79% showed suspicious masses or calcifications on mammography.
Conclusions:
- Nonspecific nipple-areolar complex thickening requires correlation with physical examination.
- Mammographic findings can be normal or abnormal in Paget disease of the nipple.