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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition

K M Dolwick1, H I Swanson, C A Bradfield

  • 1Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.

Proceedings of the National Academy of Sciences of the United States of America
|September 15, 1993
PubMed

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...