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Reduced [3H]SCH 23390 binding and DA-sensitive adenylyl cyclase in the limbic system of ethanol-preferring rats
M G De Montis1, C Gambarana, G L Gessa
1Institute of Pharmacology, University of Siena, Italy.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|July 1, 1993
Abstract:
Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.