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N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities
O Bruno1, A Ranise, F Bondavalli
1Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1993
Abstract:
The synthesis of N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines by reaction of N-substituted 3-oxo-2,3-diphenylpropane-carbothioamides with hydrazine is described. Some compounds showed remarkable antipyretic, antiarrhythmic and hypotensive activity in rats, as well as weak antiinflammatory, analgesic and in vitro platelet antiaggregating activity.