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Schizophrenia: a neurodevelopmental perspective

L S Pilowsky1, R W Kerwin, R M Murray

  • 1Genetics Section, Institute of Psychiatry, Denmark Hill, London.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|August 1, 1993
PubMed
Summary
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Aberrant neurodevelopment, potentially influenced by genetic defects and environmental factors like obstetric complications, may cause schizophrenia. This leads to brain abnormalities, particularly in young males, presenting with early symptoms and neurological signs.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia etiology is complex, involving neurodevelopmental disruptions.
  • Neuropathologic, neurochemical, and neuroimaging studies reveal cerebral abnormalities in patients.
  • Genetic factors may impair brain development control.

Framework:

  • This review examines evidence linking neurodevelopmental aberrations to schizophrenia.
  • It integrates findings from neuropathology, neurochemistry, and neuroimaging.
  • The focus is on early brain development and its potential disruptions.

Implementation:

  • Clinical epidemiologic surveys identify key risk factors.
  • Obstetric complications are highlighted as contributing factors.
  • Prenatal exposure to influenza epidemics is implicated.

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Implications:

  • Environmental hazards and developmental aberrations create a neuronal phenotype for schizophrenia.
  • Schizophrenia may manifest with early symptom onset and soft neurological signs.
  • The condition appears more prevalent in young males.