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Myocardial preservation using HTK solution for heart transplantation. A multicenter study
H Reichenspurner1, C Russ, P Uberfuhr
1Department of Cardiac Surgery, University of Munich-Grosshadern, Germany.
Summary
Bretschneider HTK solution offers good myocardial preservation for heart transplantation. However, prolonged ischemic times significantly increase acute graft failure and early mortality, underscoring the importance of timely organ reperfusion.
Area of Science:
- Cardiology
- Transplantation Medicine
- Surgical Research
Background:
- Bretschneider HTK solution is a widely used agent for myocardial preservation during heart transplantation.
- Optimizing organ preservation is critical for successful heart transplant outcomes.
Purpose of the Study:
- To evaluate the protective effect of Bretschneider HTK solution in heart transplantation.
- To identify factors influencing graft survival and patient mortality in heart transplant recipients.
Main Methods:
- A retrospective study involving 600 heart transplantations (1981-1991) across five centers.
- Data collected included donor/recipient factors, immunosuppression, and organ function.
- Statistical analysis using the chi2-test to correlate ischemic time and perfusion volume with outcomes.
Main Results:
- Average ischemic time was 160 minutes (range: 75-304 min).
- 4.2% immediate graft failure and 11.8% failure within 30 days were observed.
- Increased ischemic time (P=0.01) and perfusion volume < 1500 ml correlated with higher early graft failure.
Conclusions:
- Bretschneider HTK solution provides good results for myocardial preservation in heart transplantation when ischemic time is under 4 hours.
- Minimizing ischemic time is crucial for reducing acute graft failure and early mortality.
- Further research is needed to explore the impact of increased perfusion volume on extending ischemic times.