[A case of acute pancreatitis during administration of valproic acid]

We reported a case of acute pancreatitis occurring during administration of valproic acid for epilepsy. About four years prior to the first onset of acute pancreatitis, treatment with valproic acid for his seizures was started. The first pancreatitis improved by conservative therapy within a week. He continued valproic acid after the first episode. Two months later, the second acute pancreatitis occurred. The second episode was complicated with disseminated intravascular coagulation, but responded to conservative therapy. After the second episode, the valproic acid was discontinued and pancreatitis has not recurred. Pancreatitis associated with valproic acid may be severe, and therefore valproic acid should be used with caution.