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[DNA as a prognostic factor in colorectal cancer. A retrospective analysis of 34 patients]
A Bianchi1, C Mallofre, A Serrano
1Servicio Cirugía General, Consorci Sanitari de Mataró, Hospital Sant Jaume i Sta. Magdalena.
Objective:
We study the tumoral DNA as a prognostic factor in patients operated for colo-rectal cancer.
Design:
Retrospective. We analyze by flow cytometry the DNA content of tumoral tissue: Ploidy, DNA Index, Proliferative Index, S Phase.
Patients:
34 operated patients, for colo-rectal cancer, with a minimum 3 years of follow-up.
Results:
Ploidy doesn't show any relation with other prognostic factors. Only Dukes C aneuploid patients had more positive nodes than diploid. Ploidy was not related to better evolution or survival. Neither DNA Index, Proliferative Index and S Phase were related to the evolution of the disease.
Conclusions:
The DNA study by flow cytometry has no better prognostic value then other classical factors.