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New patch delivery system for percutaneous local anaesthesia

D F McCafferty¹, A D Woolfson

¹School of Pharmacy, Queen's University of Belfast.

British Journal of Anaesthesia

|September 1, 1993

Summary

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A new amethocaine patch offers efficient topical anaesthesia, with the stratum corneum acting as a drug reservoir. A 30-minute patch application provided prolonged anaesthesia, outperforming EMLA in duration.

Area of Science:

Dermatology
Pharmacology
Drug Delivery Systems

Background:

Topical local anaesthesia is crucial for procedures.
Optimizing drug delivery and efficacy remains a key challenge.
Amethocaine is a potent local anaesthetic agent.

Purpose of the Study:

To evaluate a novel amethocaine patch for topical anaesthesia.
To compare its efficacy and diffusion characteristics against a gel formulation.
To investigate the role of stratum corneum in amethocaine delivery.

Main Methods:

In vitro and in vivo assessment of amethocaine release and skin diffusion.
Comparative study of a new patch versus an amethocaine gel.
Double-blinded clinical trial with varying application times (30 and 60 minutes).

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Main Results:

The amethocaine patch demonstrated superior release efficiency compared to the gel.
The stratum corneum functioned as an effective amethocaine reservoir.
No significant difference in onset of anaesthesia between patch and gel at comparable application times.
A 30-minute patch application achieved profound and prolonged anaesthesia.
The amethocaine patch provided longer duration of action than EMLA, even with shorter application time.

Conclusions:

The novel amethocaine patch is an effective system for topical anaesthesia.
The stratum corneum plays a significant role in enhancing amethocaine's reservoir effect.
The patch offers a promising alternative for percutaneous local anaesthesia, with improved duration compared to existing formulations like EMLA.