Related Experiment Video
Updated: Aug 2, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Astigmatism after penetrating keratoplasty using the Krumeich guided trephine system
S C Belmont1, J L Zimm, R L Storch
1Manhattan Eye, Ear, and Throat Hospital, New York, NY.
Background:
The use of a suction trephine during penetrating keratoplasty has the potential to reduce trephination errors and astigmatism after suture removal.
Methods:
In this study, we evaluated refractive astigmatism after suture removal in 26 eyes that had penetrating keratoplasty for keratoconus using refraction, keratometry, and videokeratography. Group I (11 eyes) had manual trephination with an open disposable blade of both the donor (8.2 mm) and the recipient (8.0 mm). Group II (10 eyes) had manual trephination with an open disposable blade of the donor (8.2 mm) and Krumeich guided trephine system trephination of the recipient (8.0 mm). Group III (5 eyes) had guided trephination of both the donor (8.0 mm) and the recipient (8.0 mm).
Results:
The guided trephine groups II and III demonstrated statistically significant less refractive cylinder when compared to manual trephination group I (p < .01). The mean keratometric cylinder for group I was 6.50 diopters (D) (range, 1.50 to 9.00 D), for group II was 3.00 D (range, 0.50 to 7.00 D), and for group III was 2.55 D (range, 0 to 4.00 D).
Conclusion:
The Krumeich guided trephine system produced less keratometric astigmatism than manual trephination after penetrating keratoplasty for keratoconus.

