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2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media
O Bekers1, J H Beijnen, M J Tank
1Department of Clinical Chemistry, Leyenburg Hospital, The Hague, The Netherlands.
Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1993
Abstract:
The chemical stability of 2',3'-dideoxyinosine has been studied over a wide pH range (0-12). A stability-indicating HPLC method was used to separate the degradation product from the parent drug. The effects of temperature, ionic strength and buffer components on the degradation kinetics were investigated. Furthermore, the influence of some cyclodextrins (alpha-, beta-, HP-beta-, DM-beta- and gamma-cyclodextrin) on the drug stability have been studied.