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Related Experiment Videos

Bilateral renal lymphosarcoma in a dog

D Zhao1, R Yamaguchi, S Tateyama

  • 1Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan.

The Journal of Veterinary Medical Science
|August 1, 1993
PubMed
Summary

A rare kidney lymphosarcoma metastasized to ovaries and heart in a Shiba dog. This canine cancer caused severe clinical signs including vomiting, diarrhea, and hypoglycemia.

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Area of Science:

  • Veterinary Pathology
  • Canine Oncology
  • Comparative Pathology

Background:

  • Lymphosarcoma is a common malignancy in dogs, but primary renal origin is rare.
  • Metastatic patterns of canine cancers can vary, impacting diagnosis and prognosis.
  • Understanding tumor cell morphology is crucial for accurate pathological classification.

Observation:

  • A 3-year-old female Shiba dog presented with vomiting, diarrhea, oliguria, abdominal enlargement, and hypoglycemia.
  • Gross examination revealed enlarged kidneys with neoplastic masses in the ovaries and heart.
  • Histopathology showed diffuse invasion of renal glomeruli and tubules by small- to medium-sized lymphoid cells.

Findings:

  • A primary renal lymphosarcoma was diagnosed, with metastasis to the ovaries, oviducts, heart, and pancreas.

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  • No evidence of metastasis was found in mesenteric lymph nodes, tracheobronchial lymph nodes, spleen, or bone marrow.
  • Tumor cells were characterized as small- to medium-sized lymphoid cells with large nuclei and scant cytoplasm.

    • Implications:

    • This case highlights the importance of considering primary renal lymphosarcoma in dogs presenting with renal and systemic signs.
    • The observed metastatic pattern provides valuable data for veterinary oncologists and pathologists.
    • Further research into the specific oncogenesis and behavior of renal lymphosarcoma in dogs is warranted.