Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in plasma copper and zinc during rat development

E Martínez Lista1, J Solé, L Arola

  • 1Universitat Rovira i Virgili, Departamento Bioquímica i Biotecnologia, Tarragona, Espanya.

Biology of the Neonate
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019).

The Journal of small animal practice·2023
Same author

Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study.

Scientific reports·2021
Same author

Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study).

Molecular nutrition & food research·2021
Same author

Summary of recommendations and key points of the consensus of Spanish scientific societies (SEPAR, SEMICYUC, SEMES; SECIP, SENEO, SEDAR, SENP) on the use of non-invasive ventilation and high-flow oxygen therapy with nasal cannulas in adult, pediatric, and neonatal patients with severe acute respiratory failure.

Medicina intensiva·2021
Same author

Summary of recommendations and key points of the consensus of Spanish scientific societies (SEPAR, SEMICYUC, SEMES; SECIP, SENEO, SEDAR, SENP) on the use of non-invasive ventilation and high-flow oxygen therapy with nasal cannulas in adult, pediatric, and neonatal patients with severe acute respiratory failure.

Medicina intensiva·2020
Same author

Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein.

Antimicrobial agents and chemotherapy·2019
Same journal

Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis.

Biology of the neonate·2006
Same journal

Can cerebrospinal fluid uric acid levels differentiate intraventricular hemorrhage from traumatic tap?

Biology of the neonate·2006
Same journal

Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain.

Biology of the neonate·2006
Same journal

Thymus involution and cerebral white matter damage in extremely low gestational age neonates.

Biology of the neonate·2006
Same journal

Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature.

Biology of the neonate·2006
Same journal

Systemic and pulmonary effects of vasopressors and inotropes in the neonate.

Biology of the neonate·2006
See all related articles

Copper and zinc plasma levels change significantly during rat development. Copper rises post-birth with ceruloplasmin, while zinc decreases from prenatal levels, associating with albumin.

Area of Science:

  • * Biochemistry
  • * Developmental Biology
  • * Trace Element Metabolism

Background:

  • * Perinatal development involves dynamic changes in essential trace elements.
  • * Understanding copper and zinc metabolism is crucial for developmental health.
  • * Plasma protein binding influences trace element bioavailability.

Purpose of the Study:

  • * To investigate the developmental changes in copper and zinc binding to plasma ligands during the rat perinatal period.
  • * To correlate these changes with specific plasma proteins and enzyme activity.

Main Methods:

  • * Column chromatography (Sephadex G-150) was employed to separate plasma proteins.
  • * Atomic absorption spectrophotometry was used for quantifying copper and zinc concentrations.

Related Experiment Videos

  • * Ceruloplasmin activity was measured to assess its role in copper transport.

    • Main Results:

    • * Plasma copper levels were low at birth, increasing sharply after day 10, mirroring ceruloplasmin activity and its copper association.
    • * Plasma zinc levels were higher prenatally, gradually decreasing to adult values.
    • * Zinc's association with albumin and other proteins followed the pattern of decreasing plasma zinc.

    Conclusions:

    • * Copper and zinc exhibit distinct developmental trajectories in rat plasma during the perinatal period.
    • * Ceruloplasmin plays a key role in the postnatal surge of copper transport.
    • * Albumin and associated proteins are primary carriers for zinc, with their binding capacity reflecting developmental zinc levels.