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Regional blood flow redistribution due to acetate
D R Buyer1, R L Krahmer, A H Lau
1Department of Research (151), VA Westside Hospital, Chicago, IL 60612.
Journal of the American Society of Nephrology : JASN
|July 1, 1993
Summary
Acetate infusion in conscious rats significantly increased blood flow to the splanchnic organs and kidneys without altering central hemodynamics. This study reveals acetate
Area of Science:
- Physiology
- Cardiovascular Research
- Metabolic Studies
Background:
- Limited data exists on acetate's impact on regional blood flow in conscious animals.
- Understanding acetate's physiological effects is crucial for metabolic and cardiovascular research.
Purpose of the Study:
- To investigate the effects of acetate infusion on regional organ blood flow in unanesthetized rats.
- To determine if acetate influences central hemodynamics or alters blood flow distribution.
Main Methods:
- Conscious rats received isosmolal sodium acetate or saline infusions.
- Tracer-tagged microspheres were used to measure cardiac output and organ blood flow.
- Plasma acetate levels were maintained at approximately 2.06 mM.
Main Results:
- Acetate infusion significantly increased blood flow to the splanchnic bed (+40%), heart (+33%), and kidneys (+29%).
- No significant changes were observed in cardiac output, total peripheral vascular resistance, or arterial blood gases.
- Cerebral blood flow and flow to skeletal muscle and fat remained largely unaffected.
Conclusions:
- Low plasma acetate levels can induce a marked redistribution of blood flow towards splanchnic organs and kidneys.
- Acetate's effects on regional perfusion occur independently of changes in overall systemic vascular resistance.
- These findings highlight acetate's role in modulating regional blood flow distribution in physiological conditions.