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Lack of increase or reduction in circulating platelet factor 4 and heparin-releasable platelet factor 4 in
G Luzzatto1, G Cella, P Boschetto
1Chair of Hematology, Padua University School of Medicine, Italy.
Journal of Lipid Mediators
|June 1, 1993
Abstract:
We measured circulating platelet factor 4 (PF4) and heparin-releasable platelet factor 4 (HR-PF4) in 13 symptomatic patients suffering from bronchial asthma and in 10 matched normal controls. Neither a difference between patients and controls, nor a correlation between platelet count and HR-PF4 was found (PF4: controls 2.1 +/- 2.9; patients 3.6 +/- 4.4 ng/ml (n.s.); HR-PF4: controls 127 +/- 49, patients 101 +/- 34 ng/ml (n.s.). Therefore, the pathogenetic role of PF4 in the mechanism of bronchial asthma, elsewhere hypothesized, cannot definitely be established.