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Adhesion molecules in tumor metastasis

B R Zetter1

  • 1Department of Physiology, Harvard Medical School and Children's Hospital, Boston, MA 02115.

Seminars in Cancer Biology
|August 1, 1993
PubMed
Summary

Adhesive molecules critically influence cancer metastasis by mediating tumor cell adhesion to blood vessels and tissues. Understanding these interactions is key to developing strategies to inhibit the spread of cancer. Keywords: cancer metastasis, adhesion molecules, tumor cell adhesion.

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Metastatic tumor dissemination is a complex process critically dependent on adhesive interactions.
  • Adhesion molecules modulate metastatic potential, with some (e.g., E-cadherin) inhibiting and others promoting metastasis.

Purpose of the Study:

  • To review the role of cell surface adhesion molecules in cancer metastasis.
  • To highlight molecules correlating with metastasis in human tumors or experimental models.

Main Methods:

  • Literature review of studies on adhesion molecules in cancer metastasis.
  • Emphasis on molecules with clinical relevance or demonstrated impact in experimental assays.

Main Results:

  • Adhesion molecules mediate multiple steps of metastasis: initial arrest in vasculature, transmigration through vessel walls, and invasion into secondary sites.
  • Specific molecules like Sialyl LewisX, VLA-4, E-selectin, VCAM-1, LuECAM, integrins (beta 1, beta 4), and CD44 are implicated.
  • Both positive and negative modulators of metastasis exist, acting in concert to direct tumor cells.

Conclusions:

  • Cell surface adhesion molecules are crucial regulators of metastatic potential and organ specificity.
  • Targeting these adhesion molecules offers potential therapeutic strategies against cancer spread.

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