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[The effect of low doses of dexamethasone on interleukin-2 production by human peripheral blood lymphocytes]
Dose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated. In four independent experiments with PBL of 10 human subjects the effect of Dx administration on IL-2 release in serum-free culture medium could vary from appreciable enhancing to complete suppression. The enhancing effect was observed distinctly with PBL of 7 individuals. A transition from stimulation to suppression of IL-2 production by Dx was essentially observed in the dose range of 10(-9) to 10(-8) M. Thus the glucocorticoid hormones can both increase and decrease the production of L-2 which occupies a central position in the cascade of events involved in the immune response. Mechanisms of IL-2 release modification by Dx are discussed.
Dose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated. In four independent experiments with PBL of 10 human subjects the effect of Dx administration on IL-2 release in serum-free culture medium could vary from appreciable enhancing to complete suppression. The enhancing effect was observed distinctly with PBL of 7 individuals. A transition from stimulation to suppression of IL-2 production by Dx was essentially observed in the dose range of 10(-9) to 10(-8) M. Thus the glucocorticoid hormones can both increase and decrease the production of L-2 which occupies a central position in the cascade of events involved in the immune response. Mechanisms of IL-2 release modification by Dx are discussed.