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Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity
I M Longini1, M E Halloran, M Haber
1Division of Biostatistics, Emory University School of Public Health, Atlanta, Georgia.
Mathematical Biosciences
|September 1, 1993
Abstract:
A stochastic epidemic model is formulated for the study of the protective effects of vaccination in a population that is stratified by vaccine-related factors. The epidemic model is transformed into a counting process, and then martingale-based methods are used to provide estimators of vaccine efficacy and their variances. Following an example, various extensions of the model are discussed.