Recurrent angioedema caused by circulating immune complexes containing antibodies against bovine proteins

A 27-year-old woman with severe recurrent angioedema and urticaria since 5 years was found to have high levels of circulating immune complexes in the peripheral blood. These immune complexes contained antibodies against bovine serum albumin. Elimination of bovine products from the diet resulted in disappearance of immune complexes within 2 days and addition again to the diet led to reappearance within 24 h. The patient has now been in complete remission during 4.5 years under treatment with a diet free of bovine proteins but containing products from chicken, egg, pork and fish. The immune complexes have not reappeared. Thus, immune complexes containing antibodies against alimentary antigens can provoke acute vascular damage manifested as angioedema and urticaria. In such cases, elimination of the causative antigen from the diet can result in patient being cured.