The joys and vicissitudes of protein science

A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.

Science (New York, N.Y.)·2001

Propagating conformational changes over long (and short) distances in proteins.

Proceedings of the National Academy of Sciences of the United States of America·2001

Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.

Biochemistry·2001

Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.

Biochemistry·2000

Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.

Glycobiology·2000

Sites of binding and orientation in a four-location model for protein stereospecificity.

IUBMB life·2000

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.

Protein science : a publication of the Protein Society·2026

Catalytic architecture and cyclase-mediated dimerization of a newly identified class III-c lanthipeptide synthetase.

Protein science : a publication of the Protein Society·2026

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.

Protein science : a publication of the Protein Society·2026

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation.

Protein science : a publication of the Protein Society·2026

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition.

Protein science : a publication of the Protein Society·2026

Viral PDZ target sequences are not inherently more promiscuous than those derived from endogenous target proteins.

Protein science : a publication of the Protein Society·2026

The Translocation of Circular DNA with Variable Single/Double Strand Ratios through Solid-State Nanopores: Transition from Entropic Barriers to Crowding-Dominated Kinetics.

ACS applied materials & interfaces·2026

Collision-Induced Dissociation Study of Isomeric Tetrahydrocarbazole Carboxylic Acids Relevant to Corrosive Petroleum Crudes.

Journal of the American Society for Mass Spectrometry·2026

Native yeast kinetochore structures identify an essential inner kinetochore interaction.

Nature communications·2026

Carbene-Stabilized Monomeric Cyanogen N-Oxide.

Journal of the American Chemical Society·2026

The advent of molecular nanocarbon biology.

Chemical science·2026

Cis glycan-glycan interactions organize membrane nanodomains that tune receptor signaling.

Nature communications·2026

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The joys and vicissitudes of protein science

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A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.

Propagating conformational changes over long (and short) distances in proteins.

Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.

Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.

Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.

Sites of binding and orientation in a four-location model for protein stereospecificity.

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.

Catalytic architecture and cyclase-mediated dimerization of a newly identified class III-c lanthipeptide synthetase.

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation.

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition.

Viral PDZ target sequences are not inherently more promiscuous than those derived from endogenous target proteins.

The Translocation of Circular DNA with Variable Single/Double Strand Ratios through Solid-State Nanopores: Transition from Entropic Barriers to Crowding-Dominated Kinetics.

Collision-Induced Dissociation Study of Isomeric Tetrahydrocarbazole Carboxylic Acids Relevant to Corrosive Petroleum Crudes.

Native yeast kinetochore structures identify an essential inner kinetochore interaction.

Carbene-Stabilized Monomeric Cyanogen N-Oxide.

The advent of molecular nanocarbon biology.

Cis glycan-glycan interactions organize membrane nanodomains that tune receptor signaling.

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