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Pneumococcal arthritis after allogeneic bone marrow transplantation
N Schwella1, R Schwerdtfeger, I Schmidt-Wolf
1Medizinische Klinik mit Schwerpunkt Hämatologie/Onkologie, Freie Universität Berlin, Germany.
Abstract:
We report a case of pneumococcal arthritis occurring in a 15-year-old boy following allogeneic BMT. The post-transplant course was complicated by GVHD requiring prolonged immunosuppressive therapy. He experienced recurrent infections, including pneumococcal pneumonia. Thirty-five months after BMT and 12 months after the pneumococcal pneumonia, pneumococcal arthritis of the left knee occurred. This is the first reported case of arthritis caused by Streptococcus pneumoniae after allogeneic BMT. Penicillin prophylaxis may be used to prevent recurrence of pneumococcal infections in patients with chronic GVHD.
Insights
This case study details pneumococcal arthritis in a teen post-allogeneic bone marrow transplant (BMT). Recurrent infections, including pneumonia, preceded the arthritis, highlighting potential preventative strategies.
Area of Science:
- Hematology
- Immunology
- Infectious Diseases
Background:
- Allogeneic bone marrow transplantation (BMT) can lead to complications like graft-versus-host disease (GVHD).
- Patients undergoing BMT, especially with GVHD and immunosuppression, are at increased risk for recurrent infections.
- Streptococcus pneumoniae is a common pathogen causing infections in immunocompromised individuals.