Related Experiment Video
Updated: Aug 18, 2026

Optimal Preparation of Formalin Fixed Samples for Peptide Based Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Workflows
Published on: January 16, 2018
Effects of preparation methods of biomedical samples on PIXE measurement sensitivity
T Kupila-Rantala1, M Hyvönen-Dabek, J Räisänen
1University of Helsinki, Department of Physics, Finland.
Abstract:
Instrumental sample preparation techniques for PIXE measurements of human blood serum and bovine muscle were investigated. The techniques studied were direct measurement of a drop, drying on a foil and on an Al cup, lyophilization on a foil, pellet pressing of dried material, microtome sectioning and biopsy preparation. The same serum and muscle were used in each procedure allowing the comparison of detection limits between different methods. The most beneficial technique for both samples was lyophilization and pellet pressing.
Related Concept Videos
Preparation of Samples for Electron Microscopy
Sample Preparation for Analysis: Overview
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...

