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Related Experiment Videos

Basic fibroblast growth factor accelerates wound healing in chronically ischaemic tissue

E Uhl1, J H Barker, I Bondàr

  • 1Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany.

The British Journal of Surgery
|August 1, 1993
PubMed
Summary

Recombinant human basic fibroblast growth factor (bFGF) significantly improved wound healing in ischemic skin tissue. This growth factor shows potential for treating wounds in compromised tissue environments.

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Area of Science:

  • Regenerative Medicine
  • Wound Healing Research
  • Dermatology

Background:

  • Ischaemic tissue presents a significant challenge for wound healing due to impaired blood supply and reduced nutrient delivery.
  • Basic fibroblast growth factor (bFGF) is a potent mitogen and angiogenic factor involved in tissue repair processes.

Purpose of the Study:

  • To investigate the efficacy of subcutaneously injected recombinant human basic fibroblast growth factor (bFGF) in promoting wound healing in both normal and ischaemic skin models.
  • To determine the dose-dependent effects of bFGF on wound closure rates in compromised tissue.

Main Methods:

  • Standardized 5 mm2 wounds were created on the ears of hairless mice.
  • Wounds were treated with two different doses of bFGF (720 ng and 4050 ng) or a control solution for the first 3 days post-wounding.

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  • Wound surface area was measured on days 7, 10, and 13 to assess healing progression.

    • Main Results:

    • bFGF demonstrated no significant effect on wound healing in normal (non-ischaemic) skin tissue.
    • In ischaemic skin, both low-dose (720 ng) and high-dose (4050 ng) bFGF significantly accelerated wound closure compared to controls.
    • Specifically, 720 ng bFGF reduced wound area by day 7 (P < 0.04), day 10 (P < 0.03), and day 13 (P < 0.04), while 4050 ng bFGF reduced wound area by day 7 (P < 0.006) and day 10 (P < 0.02).

    Conclusions:

    • Recombinant human basic fibroblast growth factor (bFGF) effectively promotes wound healing in ischaemic skin tissue.
    • bFGF holds promise as a therapeutic agent for managing wounds in patients with compromised tissue perfusion.