[Detection and analysis of the red cell immune function, fibronectin, complement 3 and complement 4 in patients with...

The immune function and many other physiological functions are severely interfered with in patients following burn injury. This paper reports the results of determinations of the red cell immune function, the serum concentration of fibronectin (Fn), C3 and C4 in patients with burn injury, whose third-degree burns covered 11.48 +/- 5.80%. The rosette rate of red cell C3b receptors in the patients and normal individuals were 14.28 +/- 4.58% and 17.33 +/- 4.07% (P < 0.001), and that of red cell immune complex (IC) 4.68 +/- 1.77% and 4.94 +/- 1.26 (P > 0.05), the serum Fn level 234.28 +/- 98.05 mg/L and 312.50 +/- 70.99 mg/L (P < 0.01), C3 2014.24 +/- 438.40 mg/L and 1960.00 +/- 613.30 mg/L (P > 0.05) degrees C4 601.11 +/- 84.71 mg/L and 598.24 +/- 111.09 mg/L (P > 0.05), respectively. In the patients, the rosette rate of red cell IC and the serum concentration of C3 and C4 did not change remarkably, but the rosette rate of red cell C3b receptors and the serum fibronectin level were reduced markedly in comparison with normal controls. The decrease of the last two was related to the failure of anti-infectious capacity of patients with burn injury.