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Prevention of carcinogenicity of anticancer drugs by metallothionein induction
1Department of Public Health and Environmental Medicine, Jikei University School of Medicine, Tokyo, Japan.
Cancer Research
|October 15, 1993
Abstract:
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.