Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis

P R Craddock, J Fehr, K L Brigham

    The New England Journal of Medicine
    |April 7, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term trajectories of densely reported depressive symptoms during an extended period of the COVID-19 pandemic in Switzerland: Social worries matter.

    Comprehensive psychiatry·2024
    Same author

    CAD4TB software updates: different triaging thresholds require caution by users and regulation by authorities.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
    Same author

    Evaluation of a measles vaccination campaign at the universities in the city of Zurich, 2019.

    Public health·2021
    Same author

    A systematic review and meta-analysis of first-line tuberculosis drug concentrations and treatment outcomes.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020
    Same author

    Long-term immunogenicity after yellow fever vaccination in immunosuppressed and healthy individuals.

    Vaccine·2020
    Same author

    Chemsex drugs on the rise: a longitudinal analysis of the Swiss HIV Cohort Study from 2007 to 2017.

    HIV medicine·2019
    Same journal

    Sparganosis.

    The New England journal of medicine·2026
    Same journal

    Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

    The New England journal of medicine·2026
    Same journal

    For Those Left Behind.

    The New England journal of medicine·2026
    Same journal

    Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

    The New England journal of medicine·2026
    Same journal

    Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

    The New England journal of medicine·2026
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    See all related articles

    Hemodialysis can cause lung problems in uremic patients due to white blood cell buildup. This study shows complement-mediated leukostasis is a key factor in these acute cardiopulmonary complications.

    Area of Science:

    • Nephrology
    • Pulmonary Medicine
    • Immunology

    Background:

    • Uremic patients undergoing hemodialysis can experience cardiopulmonary decompensation.
    • Leukocyte plugging of pulmonary vessels is a suspected cause.
    • Cellophane membrane hemodialysis is associated with these complications.

    Purpose of the Study:

    • To investigate the mechanism of acute cardiopulmonary complications during hemodialysis.
    • To determine the role of leukocytes and complement activation in these events.

    Main Methods:

    • Observational study in 34 uremic patients undergoing hemodialysis.
    • Animal model using rabbits and sheep infused with plasma incubated with cellophane dialyzers.
    • Complement inactivation and activation studies using zymosan.

    Related Experiment Videos

    Main Results:

    • Hemodialysis induced leukopenia and impaired pulmonary function in a subset of patients.
    • Animal models showed sudden leukopenia, hypoxia, increased pulmonary artery pressures, and pulmonary edema after plasma infusion.
    • These effects were prevented by complement inactivation and reproduced by complement activation.

    Conclusions:

    • Complement-mediated leukostasis plays a significant role in acute pulmonary dysfunction during cellophane-membrane hemodialysis.
    • This mechanism contributes to acute cardiopulmonary complications in uremic patients.
    • Understanding this pathway may lead to improved hemodialysis strategies.