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[Antimicrobial activity of diazole-(N-salicylidene-L-alpha- alaninato)-copper complexes]
M Blahová1, J Sokolík, S Sedlácková
1Katedra chemickej teórie lieciv a Katedra biochémie a mikrobiológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Abstract:
The antimicrobial activities of a group of copper(II) chelates with the composition [Cu(TSB)(L)] or [Cu(TSB)(L')]. (TSB = N-salicylidene-L-alpha-alaninate dianion, L = imidazole and its alkyl derivatives, L' = pyrazole and 3,5-dimethylpyrazole) were studied. Bis-diazole complexes with L' = pyrazole and 3,5-dimethylpyrazole were found to be the most active against S. aureus (MIC = 78 and 20 micrograms.cm-3), less effective against C. albicans (156 micrograms.cm-3), T. terrestre and M. gypseum (100 micrograms.cm-3). The observed biological properties of complexes are discussed in relation to their proposed structures.