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Updated: Aug 11, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Hyperlipoproteinemia in mentally retarded children]
J Höllge1, J Vymlátil, P Kostiuk
1Klinika dĕtského a dorostového lékarství 1. LF UK Praha.
Ceskoslovenska Psychiatrie
|August 1, 1993
Summary
Mentally retarded children show higher rates of hyperlipoproteinaemia due to secondary factors like medications and infections. Early biochemical diagnosis is crucial for managing health and preventing future cardiovascular disease.
Area of Science:
- Biochemistry
- Pediatrics
- Public Health
Context:
- Higher incidence of hyperlipoproteinaemia observed in institutionalized mentally retarded children compared to healthy peers.
- Secondary influences, including antiepileptics, neuroleptics, viral hepatitis, and other factors, significantly contribute to the etiology.
- Oligophrenia complications are primary drivers of secondary hyperlipoproteinaemia in this population.
Purpose:
- To investigate the incidence of hyperlipoproteinaemia in mentally retarded children.
- To identify etiological factors contributing to hyperlipoproteinaemia in this vulnerable group.
- To emphasize the importance of early diagnosis and its implications.
Summary:
- Screening revealed significantly higher hyperlipoproteinaemia in mentally retarded children.
- Antiepileptics, neuroleptics, viral hepatitis, and other factors are key etiological contributors.
- Biochemical methods are currently the only means for early diagnosis.
Impact:
- Early diagnosis enables essential genetic counseling.
- Facilitates prevention of mental retardation deterioration.
- Allows for pharmacotherapy restriction and reduces future cardiovascular disease risk.
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