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Conformation of tropolone ring in antileukemic tropoloisoquinoline alkaloids
H Morita1, K Matsumoto, K Takeya
1Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Chemical & Pharmaceutical Bulletin
|August 1, 1993
Abstract:
Conformational analysis of antileukemic tropoloisoquinoline alkaloids isolated from Cissampelos pareira was conducted by thermodynamic proton nuclear magnetic resonance (1H NMR) studies. The line-broadening of one of methoxy methyl signals can be explained by the tropolone ring-puckering process. Analysis by dynamical simulated annealing and modified neglect of differential overlap (MNDO) calculations also supported puckering of tropolone ring system.