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A hypothesis for chemical carcinogen induced chromatin condensation
1Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford 61107.
Carcinogenesis
|September 1, 1993
Abstract:
A hypothesis for chemical carcinogen induced condensation of nuclear and nucleolar chromatin is proposed. Chromatin condensation is believed to be a result of cascade effects initiated by the inhibition of messenger RNA synthesis after exposure to chemical carcinogen in vivo. Inhibition of messenger RNA synthesis leads to the loss of protein production, which in turn causes the dephosphorylation of histone H1 and triggers the condensation of chromatin in vivo.