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Familial cold urticaria

C M Zip1, J B Ross, M W Greaves

  • 1Dalhousie University, Halifax, Canada.

Clinical and Experimental Dermatology
|July 1, 1993
PubMed
Summary
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Familial cold urticaria (FCU) is a rare genetic disorder triggered by cold exposure, causing hives and flu-like symptoms. This study presents a new family pedigree, contributing to understanding this rare condition.

Area of Science:

  • Genetics
  • Immunology
  • Dermatology

Background:

  • Familial cold urticaria (FCU) is a rare autosomal dominant disorder.
  • Symptoms manifest upon generalized exposure to cold, particularly in damp, windy conditions.

Observation:

  • Cutaneous lesions include erythematous macules, urticarial wheals, and petechiae.
  • Systemic symptoms like fever, chills, joint pain, and nausea frequently co-occur.
  • FCU onset is typically in early life, with variable symptom severity.

Findings:

  • The pathogenesis of FCU remains largely unknown.
  • Only 10 pedigrees have been previously published globally.
  • This study details an additional extensive family pedigree with FCU.

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Implications:

  • Further investigation of this pedigree may elucidate FCU pathogenesis.
  • Understanding FCU mechanisms can lead to improved therapeutic strategies.
  • This research expands the known genetic landscape of hereditary cold urticarias.