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Related Experiment Videos

Cefepime clinical pharmacokinetics

M P Okamoto1, R K Nakahiro, A Chin

  • 1Clinical Research Division, Kaiser Permanente, Downey, California.

Clinical Pharmacokinetics
|August 1, 1993
PubMed
Summary

Cefepime, a broad-spectrum cephalosporin antibiotic, effectively treats various infections and demonstrates favorable pharmacokinetics with minimal drug accumulation. It is well-tolerated and shows no significant drug interactions.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Microbiology

Background:

  • Cefepime is a parenteral cephalosporin antibiotic.
  • It exhibits antimicrobial activity against Gram-negative and Gram-positive bacteria, including resistant strains.
  • Its stability against beta-lactamases contributes to its efficacy.

Purpose of the Study:

  • To review the antimicrobial activity, clinical uses, and pharmacokinetic profile of cefepime.
  • To assess cefepime's efficacy in treating various infections and its safety profile.
  • To understand cefepime's elimination and potential for drug accumulation.

Main Methods:

  • Review of in vitro antimicrobial activity against bacterial isolates.
  • Analysis of clinical trial data for various infections and surgical prophylaxis.
  • Pharmacokinetic studies evaluating drug distribution, metabolism, and excretion.
  • Assessment of drug interactions and patient tolerability.

Main Results:

  • Cefepime demonstrates broad-spectrum activity, including against Pseudomonas aeruginosa and resistant Enterobacteriaceae.
  • Effective in treating lower respiratory, intra-abdominal, urinary tract, and skin infections.
  • Exhibits linear pharmacokinetics with no significant accumulation in normal renal function.
  • Widely distributed in tissues and fluids, primarily eliminated renally.
  • Well-tolerated with no reported significant drug interactions.

Conclusions:

  • Cefepime is a valuable antibiotic for treating a range of bacterial infections.
  • Its favorable pharmacokinetic profile and good tolerability support its clinical use.
  • Cefepime offers a reliable option for infections caused by susceptible pathogens.

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