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Yeast sugar transporters

L F Bisson1, D M Coons, A L Kruckeberg

  • 1Department of Viticulture and Enology, University of California, Davis 95616-8749.

Critical Reviews in Biochemistry and Molecular Biology
|January 1, 1993
PubMed
Summary
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Yeast glucose transporters are complex, with multiple genes involved in sugar uptake and utilization. Some transporters may also play a role in sensing glucose, not just catabolism.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Metabolism
  • Yeast Genetics

Background:

  • Sugar transport is vital for eukaryotic cells, with glucose uptake critical for energy.
  • Glucose transporter activity and concentration regulate yeast's glycolytic flux.
  • Saccharomyces cerevisiae possesses a multigene family of sugar transporters.

Purpose of the Study:

  • To investigate the complex regulation of glucose transporters in yeast.
  • To explore the roles of various sugar carriers beyond simple catabolism.
  • To examine the potential glucose-sensing functions of these transporters.

Main Methods:

  • Molecular analysis of the Saccharomyces cerevisiae sugar transporter multigene family.
  • Gene expression analysis to assess transporter abundance.

Related Experiment Videos

  • Mutational analysis to observe phenotypic consequences.

    • Main Results:

    • Identified a multigene family of sugar transporters in Saccharomyces.
    • Observed low expression of some transporters, questioning their sole role in catabolism.
    • Point mutations in transporter genes led to pleiotropic effects, suggesting broader functions.

    Conclusions:

    • Yeast glucose transporters exhibit complex regulation and diverse roles.
    • Some transporters are implicated in glucose sensing, in addition to transport.
    • Further research is needed to fully elucidate the functions of this transporter family.