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Related Experiment Videos

Loperamide abolishes exercise-induced orocecal liquid transit acceleration

W F Keeling1, A Harris, B J Martin

  • 1Medical Sciences Program, Indiana University School of Medicine, Indiana University, Bloomington 47405.

Digestive Diseases and Sciences
|October 1, 1993
PubMed
Summary

Loperamide, an antidiarrheal, blocks exercise-induced acceleration of gut transit. This suggests loperamide may treat physical activity-related gastrointestinal symptoms.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Pharmacology

Background:

  • Mild physical activity accelerates mouth-to-large intestinal transit.
  • Loperamide is a common antidiarrheal agent.

Purpose of the Study:

  • To investigate if loperamide blunts exercise-induced acceleration of orocecal transit.
  • To evaluate loperamide's effect on gut transit during rest and exercise.

Main Methods:

  • 12 healthy subjects participated.
  • Orocecal liquid transit was measured at rest and during mild exercise (5.6 km/hr).
  • Subjects ingested 8 mg loperamide 1 hour prior to each study condition.

Main Results:

  • Loperamide treatment abolished exercise-induced acceleration of H2 excretion (mean transit time: rest 72±12 min, exercise 90±15 min, P=NS).

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  • This contrasts with controls where exercise accelerated transit (by -23±5 min).
  • Loperamide slowed transit during exercise compared to controls (90±15 min vs. 64±5 min, P=0.06).

    • Conclusions:

    • Loperamide blocks the exercise effect on upper gut transit.
    • These findings suggest loperamide could be effective in treating exercise-induced gastrointestinal symptoms.