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In vitro activity of vancomycin and teicoplanin against Staphylococcus aureus and Staphylococcus epidermidis
A Kropec1, J Huebner, M Wursthorn
1Institute for Environmental Medicine and Hospital Epidemiology, University Hospital of Freiburg, Germany.
Abstract:
In a quantitative in vitro model the activity of vancomycin and teicoplanin in two concentrations (4 x MBC and 1 mg/l) against Staphylococcus aureus and a slime-producing Staphylococcus epidermidis strain colonizing the internal surface of polyurethane and silicone catheters was studied. In comparison with vancomycin, teicoplanin achieved a significantly greater reduction (p < 0.05) in the counts of Staphylococcus aureus and Staphylococcus epidermidis adhering to both polyurethane and silicone catheters.