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Updated: Aug 15, 2026

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
The atypical antipsychotic drug amperozide enhances rat cortical and striatal dopamine efflux
E A Pehek1, H Y Meltzer, B K Yamamoto
1Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Abstract:
Previous behavioral, biochemical, and electrophysiological studies have indicated that amperozide, a putative atypical antipsychotic drug with potent 5-HT2 receptor antagonist potency, preferentially affects mesocorticolimbic, as compared to mesostriatal dopamine neurons. The present experiment utilized in vivo microdialysis to compare the effects of amperozide on dopamine efflux in medial prefrontal cortex versus caudate-putamen in the freely moving rat. The results demonstrated that amperozide produced a greater elevation of cortical dopamine. These results were similar to those observed with clozapine but not haloperidol.
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