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Cancer in pregnancy

S Kennedy1, P Yudkin, M Greenall

  • 1Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, Oxford, UK.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|October 1, 1993
PubMed
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Cancer in pregnancy is rare, with an incidence of 2.35 per 10,000 deliveries. Disease recurrence was also uncommon in this retrospective study of cancer during pregnancy.

Area of Science:

  • Obstetrics and Gynecology
  • Oncology
  • Epidemiology

Background:

  • Cancer diagnosis during pregnancy presents unique challenges for both the patient and healthcare providers.
  • Estimating the incidence of pregnancy-related cancers is crucial for understanding the scope of the problem.

Purpose of the Study:

  • To determine the incidence of de novo cancer arising during pregnancy.
  • To assess the rate of cancer recurrence in women with a prior history of the disease who become pregnant.

Main Methods:

  • A retrospective study was conducted over 11 years (1981-1991) at John Radcliffe Maternity Hospital.
  • Case records of 25,568 deliveries and 6,775 terminations of pregnancy were analyzed.
  • Follow-up was performed through general practitioners to ascertain maternal mortality and disease recurrence.

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Main Results:

  • Six cases of de novo cancer arising in pregnancy were identified, yielding an incidence of 2.35 per 10,000 deliveries.
  • One case of disease recurrence was noted among the pregnancies studied.
  • Outcomes included three deaths, one recurrence, 17 women in good health, and seven lost to follow-up by 1991.

Conclusions:

  • The incidence of de novo cancer in pregnancy is lower than previously reported figures.
  • Cancer recurrence in pregnancy appears to be infrequent, though further research may be warranted.