Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetes mellitus due to viruses--some recent developments

T M Szopa1, P A Titchener, N D Portwood

  • 1Medical Unit, Royal London Hospital, UK.

Diabetologia
|August 1, 1993
PubMed
Summary

Viral infections can lead to diabetes by directly destroying beta cells or triggering autoimmune responses. Research is ongoing to understand the specific viral mechanisms and genetic factors involved in beta cell damage and diabetes development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Viruses and diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2005
Same author

The role of viruses in human diabetes.

Diabetologia·2002
Same author

Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·1999
Same author

Simultaneous onset of type 1 diabetes mellitus in identical infant twins with enterovirus infection.

Diabetic medicine : a journal of the British Diabetic Association·1998
Same author

Conference report: CIBA Foundation meeting on enteroviruses and early childhood diabetes.

Diabetic medicine : a journal of the British Diabetic Association·1996
Same author

The effects of islet cell surface antibodies on the metabolic function of mouse islet B cells in vitro.

Acta diabetologica·1995

Area of Science:

  • Virology
  • Immunology
  • Endocrinology

Background:

  • Viruses can damage pancreatic beta cells, leading to insulin deficiency and diabetes.
  • Viral infections can cause direct beta cell destruction or trigger autoimmune reactions.
  • Long-term effects of viral infections, like congenital rubella, can manifest as diabetes years later.

Purpose of the Study:

  • To explore the diverse mechanisms by which viruses damage beta cells.
  • To investigate the role of viral infections in the etiology of diabetes.
  • To identify genetic factors in viruses that determine tropism and diabetogenicity.

Main Methods:

  • Review of case histories linking viral infections to beta cell cytolysis.
  • Analysis of autoimmune phenomena in islets following viral infections.

Related Experiment Videos

  • Investigation of picornaviruses' non-lytic effects on beta cells.
  • Genetic sequencing of diabetogenic Coxsackie B virus strains.

    • Main Results:

    • Viral infections can cause rapid or gradual beta cell loss, resulting in diabetes.
    • Autoimmune responses against beta cells are frequently triggered by viral infections.
    • Some viruses inhibit insulin synthesis and alter protein expression (e.g., interferons, HLA antigens).

    Conclusions:

    • Multiple viruses can induce diabetes through direct damage or autoimmune mechanisms.
    • Understanding viral tropism and diabetogenicity is crucial for diabetes research.
    • Further research into viral genetic determinants will elucidate diabetes pathogenesis.