[Analysis of chimeric mice bearing the fused mutation]

Interaction of cells with different genotypes and expression of Fused (Fu) gene in chimaeric mice were studied. Genetic analysis of 20 chimaeras showed that gonads of chimaeras in our experiments consisted of white component cells. The analysis of Fu gene expression in chimaeric mice supported the conclusions of the previous papers that mutations of Fu gene appeared not in the result of the hypofunction of normal allele. Two hypotheses were proposed: 1) the product of Fu gene migrates out of the mutant cells and changes the phenotype of the cells with normal allele; 2) suppressors from C57BL/6 mice influence on the penetrance of Fu gene only on the intracellular level.