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Correlation between glucose disposal and amino acids levels in hyperthyroidism
N Barzilai1, E Karnieli, D Barzilai
1Endocrine Institute, Rambam Medical Center, Haifa, Israel.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 1, 1993
Summary
In hyperthyroidism, insulin still effectively lowers glucose and amino acids. The correlation between glucose disposal and amino acid reduction persists, even with altered insulin sensitivity.
Area of Science:
- Endocrinology
- Metabolic Research
- Human Physiology
Background:
- Insulin is recognized for its role in reducing plasma glucose and amino acid levels.
- Hyperthyroidism is characterized by altered insulin sensitivity, necessitating an investigation into its metabolic effects.
Purpose of the Study:
- To investigate whether the correlation between glucose disposal and amino acid levels is maintained in hyperthyroidism.
- To compare insulin's effects on glucose and amino acid metabolism in normal and hyperthyroid individuals.
Main Methods:
- Utilized the euglycemic hyperinsulinemic clamp technique in 5 normal and 5 hyperthyroid subjects.
- Measured glucose disposal rate and serum amino acid levels before and during insulin infusion.
Main Results:
- Insulin effectively decreased plasma amino acids in all subjects.
- Hyperthyroid subjects showed a greater mean amino acid decrease (50% vs. 35%) compared to normal subjects.
- The effective insulin doses for glucose disposal and amino acid reduction were higher in hyperthyroid subjects, but remained closely correlated.
Conclusions:
- The strong correlation between glucose disposal and decreased amino acid levels is preserved in hyperthyroidism.
- This study confirms the association between glucose disposal and amino acid levels across various insulin sensitivity states.