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Transgenesis in nonmurine species
1AFRC Centre for Genome Research, University of Edinburgh, UK.
Hypertension (Dallas, Tex. : 1979)
|October 1, 1993
Summary
Transgenic technology can be applied to various animal models beyond mice, including rats, rabbits, pigs, sheep, goats, and cows. This review explores methods and applications, particularly in hypertension and cardiovascular research.
Area of Science:
- Animal biotechnology
- Transgenic animal models
- Cardiovascular research
Background:
- Mice are the primary species for transgenic research.
- Certain research applications necessitate alternative animal models.
- Transgenic technology offers powerful tools for biological and medical research.
Purpose of the Study:
- To review strategies for applying transgenic technology to non-murine species.
- To discuss the potential applications of alternative transgenic models.
- To highlight relevance in hypertension and cardiovascular research.
Main Methods:
- Review of existing literature on transgenic technology in various animal species.
- Analysis of successful transgenic applications in rats, rabbits, pigs, sheep, goats, and cows.
- Synthesis of potential research avenues using these alternative models.
Main Results:
- Transgenic technology has been successfully implemented across multiple species including rats, rabbits, pigs, sheep, goats, and cows.
- Diverse strategies exist for generating transgenic animals in these species.
- Significant potential exists for utilizing these models in specific research areas.
Conclusions:
- Alternative transgenic animal models offer valuable platforms for research beyond mice.
- The application of transgenic technology in species like rats, rabbits, and livestock can advance cardiovascular and hypertension studies.
- Expanding the use of diverse transgenic models is crucial for future scientific discovery.