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Synthesis and stability of 3-nitro-2-pyridinesulfenyl chloride (NpysCl)
K C Pugh1, L Gera, J M Stewart
1Department of Biochemistry, University of Colorado School of Medicine, Denver.
International Journal of Peptide and Protein Research
|August 1, 1993
Abstract:
3-Nitro-2-pyridinesulfenyl chloride (NpysCl) is the starting material for the synthesis of N-, O- and S-Npys-protected amino acids. Two efficient, novel synthetic routes to NpysCl are described. The stability of NpysCl was determined in a variety of solvents, with and without base, to determine the most suitable solvent and base for the synthesis of N-Npys amino acids. The syntheses of Npys-Ala and Boc-Lys(Npys) tert-butylammonium salt are also described.