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Plasma catecholamine levels in children

M Candito1, M Albertini, S Politano

  • 1Laboratoire de Biochimie, Hôpital Pasteur, Nice, France.

Journal of Chromatography
|August 11, 1993
PubMed
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Plasma catecholamine levels, including norepinephrine and epinephrine, are elevated in children up to 24 months old. Adult levels are reached between 24-36 months, with fluctuations indicating environmental sensitivity in young children.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Neuroscience

Background:

  • Conflicting literature data exists regarding plasma catecholamine concentrations in young children.
  • Established adult reference ranges for norepinephrine and epinephrine do not directly apply to pediatric populations.
  • Understanding developmental changes in catecholamine levels is crucial for accurate clinical assessment.

Purpose of the Study:

  • To determine plasma catecholamine (norepinephrine and epinephrine) concentrations in healthy children aged two days to fifteen years.
  • To establish age-specific reference ranges for pediatric plasma catecholamines.
  • To investigate the developmental trajectory of catecholamine levels from infancy to adolescence.

Main Methods:

  • Plasma samples were collected from 86 healthy children across a wide age range (two days to fifteen years).

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  • A sensitive high-performance liquid chromatography technique with electrochemical detection was employed for catecholamine quantification.
  • Statistical analysis was performed to determine age-related changes and reference intervals.

    • Main Results:

    • Plasma norepinephrine and epinephrine concentrations were significantly elevated in children up to 24 months of age.
    • A progressive decline towards adult levels was observed between 24 and 36 months of age.
    • Fluctuations in catecholamine levels were noted in younger children, potentially reflecting sensitivity to environmental factors.

    Conclusions:

    • Plasma catecholamine levels exhibit distinct developmental patterns in early childhood.
    • The variability in younger children makes blood assays less reliable for detecting catecholaminergic abnormalities under two years of age.
    • Urinary catecholamine assays are recommended for evaluating catecholaminergic status in infants and very young children due to established reference values.