Hepatic dysfunction after repeated isoflurane administration

Isoflurane, a halogenated volatile anesthetic, has not been associated with a distinct hepatic injury syndrome, as has halothane. Previous cases of suspected isoflurane-induced hepatotoxicity have been reported but questioned. We report the case of a patient without previous liver disease who developed repeated episodes of hepatitis after repeated exposures to isoflurane. Although no biopsy study was conducted, the temporal relationships illustrated in this case strengthen the argument for isoflurane-induced hepatotoxicity.