Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial preconditioning. Endogenous protection against infarction

T R Snow1, P P McKeown

  • 1Department of Surgery, University of South Florida College of Medicine.

The Journal of the Florida Medical Association
|August 1, 1993
PubMed
Summary

Myocardial infarction (MI) still causes cell death, but preconditioning offers endogenous heart protection. Understanding preconditioning mechanisms is crucial for clinical applications in cardiac injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Educational interventions in neurology: a comprehensive systematic review--reply to letter.

European journal of neurology·2013
Same author

Exercise training improves activity in adolescents with congenital heart disease.

Heart (British Cardiac Society)·2013
Same author

Educational interventions in neurology: a comprehensive systematic review.

European journal of neurology·2013
Same author

Nutritional intake and oxidative stress in chronic heart failure.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2010
Same author

Lipomatous metaplasia within an old anterior myocardial infarction.

QJM : monthly journal of the Association of Physicians·2010
Same author

Adoption and maintenance of a Mediterranean diet in patients with coronary heart disease from a Northern European population: a pilot randomised trial of different methods of delivering Mediterranean diet advice.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2009

Area of Science:

  • Cardiology
  • Cellular Biology
  • Biochemistry

Background:

  • Myocardial infarction (MI) leads to irreversible cardiomyocyte death despite advanced treatments.
  • Preconditioning represents an endogenous cardioprotective phenomenon observed in various models.
  • The precise molecular pathways underlying preconditioning remain largely unknown.

Purpose of the Study:

  • To investigate the protective mechanisms of preconditioning against myocardial infarction-induced cell death.
  • To elucidate the endogenous processes involved in cardiac protection during ischemic events.
  • To highlight the clinical significance of understanding preconditioning for future therapeutic strategies.

Main Methods:

  • Review of existing literature on preconditioning and myocardial infarction.
  • Analysis of endogenous protective pathways in cardiac tissue.
  • Exploration of potential molecular targets for therapeutic intervention.

Main Results:

  • Preconditioning demonstrates significant endogenous protection against fatal cardiac outcomes post-MI.
  • While not fully elucidated, preconditioning involves complex cellular signaling pathways.
  • Identification of key factors contributing to cardioprotection is ongoing.

Conclusions:

  • Preconditioning offers a promising endogenous strategy for mitigating myocardial infarction damage.
  • Further research into preconditioning mechanisms is essential for clinical translation.
  • Unraveling these pathways could revolutionize the treatment of ischemic heart disease.

Related Experiment Videos